BHLHE40 and RBFOX1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		BHLHE40	RBFOX1
Description		basic helix-loop-helix family member e40	RNA binding fox-1 homolog 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Nuclear Body	Nucleus Cytoplasm Trans-Golgi Network
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding	RNA Binding MRNA Binding Protein Binding Protein C-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Circadian Rhythm Anterior/posterior Pattern Specification Cell Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing RNA Transport
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	MECP2 regulates transcription factors
Drugs
Diseases
GWAS		Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 25085501) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Brain glucose metabolism (fluorodeoxyglucose uptake) ( 30596066) Brain volume in infants (cerebrospinal fluid) ( 28763065) Cerebellum white matter volume ( 31530798) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive decline rate in late mild cognitive impairment ( 26252872) Depression ( 29700475) Extraversion ( 27918536) Feeling worry ( 29500382) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Glaucoma ( 25027321) Hydrolysed wheat protein allergy ( 31301374) Hyperopia ( 25233373) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intelligence (MTAG) ( 29326435) Intracranial aneurysm ( 29531279) Major depressive disorder ( 27479909 29728651) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 31628463) Myopia ( 27182965 25233373) Neurociticism ( 29500382) Neurofibrillary tangles ( 31497858) Neuroticism ( 29255261) Nickel levels ( 26025379) Obesity (extreme) ( 31852448) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) Pit-and-Fissure caries ( 24556642) Refractive astigmatism ( 30306274) Refractive error ( 23396134 23474815) Renal cell carcinoma ( 31231134) Rheumatoid arthritis ( 30423114) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemising ( 31508503) Systolic blood pressure ( 30224653) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 30130595) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		51 interacting genes: AAMP AANAT APH1A ARNTL BHLHE41 BRD7 CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 GMCL2 HDAC1 HIVEP1 HNRNPLL KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMARCB1 SMYD1 SOX15 STAT3 STK19 TCF3 TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I VAC14 VIM ZHX1	34 interacting genes: ALG13 ATN1 ATXN1 ATXN2 BHLHE40 C1orf94 CELF3 CRX DAB1 DAZAP2 DMRTB1 DVL2 FAM168A GCA HNRNPF HSFX1 HSFY1 KIFAP3 LZTS2 MAGED1 NOC2L NUMBL PCBP4 PRR20A PRRC2A PSMF1 QKI RBFOX2 RBM24 RBPMS RHOXF2 SNRPN STRBP TNIP1
Entrez ID		8553	54715
HPRD ID		16050	16091
Ensembl ID		ENSG00000134107	ENSG00000078328
Uniprot IDs		O14503 Q6IB83	B7Z1U7 Q59HD3 Q9NWB1 X5D7T5 X5DNY3 X5DP44
PDB IDs			2ERR 2N82 4ZKA
Enriched GO Terms of Interacting Partners?
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