BHLHE40 and SMYD1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		BHLHE40	SMYD1
Description		basic helix-loop-helix family member e40	SET and MYND domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Nuclear Body	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding	DNA Binding Transcription Corepressor Activity Protein Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Circadian Rhythm Anterior/posterior Pattern Specification Cell Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis	Chromatin Remodeling Heart Development Positive Regulation Of Myotube Differentiation Histone Lysine Methylation Skeletal Muscle Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Night sleep phenotypes ( 27126917)
Interacting Genes		51 interacting genes: AAMP AANAT APH1A ARNTL BHLHE41 BRD7 CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 GMCL2 HDAC1 HIVEP1 HNRNPLL KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMARCB1 SMYD1 SOX15 STAT3 STK19 TCF3 TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I VAC14 VIM ZHX1	18 interacting genes: BHLHE40 C11orf16 C11orf53 CCDC113 FAM204A H3-5 HDAC2 HDAC3 HOMEZ LENG8 MYH7B NACA OGDHL RBM4B TTC33 UTP14A WDR77 ZBTB44
Entrez ID		8553	150572
HPRD ID		16050	06025
Ensembl ID		ENSG00000134107	ENSG00000115593
Uniprot IDs		O14503 Q6IB83	E9PHG3 Q5HYE8 Q8NB12
PDB IDs
Enriched GO Terms of Interacting Partners?
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