BLZF1 and BCL6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		BLZF1	BCL6
Description		basic leucine zipper nuclear factor 1	BCL6 transcription repressor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus	Nucleus Nucleoplasm Replication Fork Golgi Apparatus
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Golgi Organization Golgi To Plasma Membrane Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Negative Regulation Of B Cell Apoptotic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Protein Localization Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Memory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Cellular Senescence
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization	Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes
Drugs
Diseases			Hairy-cell leukemia
GWAS			Adverse response to drug ( 30420678) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) B cell non-Hodgkin lymphoma ( 23749188) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Blood urea nitrogen levels ( 29403010) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340) Multiple sclerosis ( 31604244) PR interval ( 23534349) Pulmonary function (smoking interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Type 2 diabetes ( 25760438)
Interacting Genes		52 interacting genes: AKAP9 AMOTL2 BANP BCL6 BEX2 CARD9 CCDC33 CHCHD3 CINP CKS2 DNMT3L EWSR1 FBF1 FHL2 FRMD6 GEM GORASP2 HCLS1 HOXA1 IQUB KDM1A KLHL38 LMO1 LMO2 OAZ3 PRKAB2 PRMT6 PSMA1 PTPN11 RAB2A RAB2B RAB39A RANBP3 RHOJ SCNM1 SELENOS SMAD3 SMARCB1 SRA1 SSX2 SUV39H2 TBC1D7 TRAPPC2L TSC22D4 TXNDC5 VPS28 ZBTB24 ZGPAT ZMAT1 ZNF410 ZNF688 ZZZ3	61 interacting genes: ARHGEF9 BCL11A BCL6B BCOR BLZF1 CABP4 CDK19 CDK8 CHD3 CRBN CREBBP CTNNB1 CUTC DVL2 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 LIMS3 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PELI1 PIN1 PML PPARD PRKD3 RAF1 RUNX1T1 SIAH1 SIN3A SP1 SPI1 SSX2IP TFIP11 TLE5 TP53 TRAF1 TWIST1 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B
Entrez ID		8548	604
HPRD ID		16367	00180
Ensembl ID		ENSG00000117475	ENSG00000113916
Uniprot IDs		Q9H2G9	B5B0A5 P41182
PDB IDs			1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8
Enriched GO Terms of Interacting Partners?
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