BCL6 and CDK8

Number of citations of the paper that reports this interaction (PubMedID 22668559)
6

Data Source:
BioGRID (pull down, pull down)

		BCL6	CDK8
Description		BCL6 transcription repressor	cyclin dependent kinase 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Golgi Apparatus	Nucleus Nucleoplasm Nucleolus Mediator Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Negative Regulation Of B Cell Apoptotic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Protein Localization Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Memory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Cellular Senescence	Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs			Alvocidib
Diseases		Hairy-cell leukemia
GWAS		Adverse response to drug ( 30420678) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) B cell non-Hodgkin lymphoma ( 23749188) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Blood urea nitrogen levels ( 29403010) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340) Multiple sclerosis ( 31604244) PR interval ( 23534349) Pulmonary function (smoking interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Type 2 diabetes ( 25760438)	Immune response to measles-mumps-rubella vaccine ( 24811271) Sporadic pituitary adenoma ( 26029870)
Interacting Genes		61 interacting genes: ARHGEF9 BCL11A BCL6B BCOR BLZF1 CABP4 CDK19 CDK8 CHD3 CRBN CREBBP CTNNB1 CUTC DVL2 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 LIMS3 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PELI1 PIN1 PML PPARD PRKD3 RAF1 RUNX1T1 SIAH1 SIN3A SP1 SPI1 SSX2IP TFIP11 TLE5 TP53 TRAF1 TWIST1 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B	29 interacting genes: BCL6 CCNC CCNH CDKN2B CTDP1 ERCC3 ESR1 ESR2 H3C14 MAML1 MBP MED12 MED21 MED25 MED26 MED8 MED9 MYC NRIP1 POLR2A PRMT5 SMAD2 SMAD3 SMARCA4 SREBF1 SUZ12 TOP1 TP53 WDR77
Entrez ID		604	1024
HPRD ID		00180	04422
Ensembl ID		ENSG00000113916	ENSG00000132964
Uniprot IDs		B5B0A5 P41182	P49336
PDB IDs		1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8	3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2
Enriched GO Terms of Interacting Partners?
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