LMO4 and GRHL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LMO4	GRHL2
Description		LIM domain only 4	grainyhead like transcription factor 2
Image
GO Annotations	Cellular Component	Transcription Factor Complex Cell Leading Edge	Nuclear Chromatin Nucleus Nucleoplasm Cell-cell Junction Membrane
	Molecular Function	Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	Neural Tube Closure Ventricular Septum Development Transcription By RNA Polymerase II Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Protein Complex Assembly Positive Regulation Of Kinase Activity Regulation Of Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Regulation Of Cell Activation	Neural Tube Closure Cardiac Ventricle Morphogenesis Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Cell Adhesion Brain Development Cell Proliferation Epidermis Development Neural Tube Development Cell Junction Assembly Multicellular Organism Growth Embryonic Digit Morphogenesis Camera-type Eye Development Regulation Of DNA Methylation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Telomerase Activity Face Development Lung Lobe Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching Anterior Neural Tube Closure Bicellular Tight Junction Assembly Epithelium Migration
Pathways
Drugs
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Breast cancer ( 27354352) Eosinophil counts ( 29403010) Gait rhythm ( 26219847) Glaucoma (primary open-angle) ( 29891935) Photic sneeze reflex ( 27182965) Prostate-specific antigen levels ( 28139693) Response to TNF antagonist treatment ( 18615156) Resting heart rate ( 27798624) White blood cell count (basophil) ( 29403010) White blood cell types ( 21738478)	Bronchopulmonary dysplasia ( 23897914) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		53 interacting genes: AMOT AMOTL2 BANP BRCA1 CALCOCO2 CCDC102B CEP170P1 CSNK2B DDB1 DEAF1 ERCC6L GABPB1 GADD45A GOLGA2 GRHL2 GSK3B ITSN1 KANK2 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT40 LDB1 LDB2 MERTK MTA1 NFYC NHLH1 NONO PDE4DIP PITPNB PLK1 PPARG RBBP8 RBPMS RPS6KA6 SEC24D SMAD4 SMAD9 TCF21 TCF4 TFIP11 TINAGL1 TLE5 TNFSF11 TP53BP2 TSEN15 VPS52 ZBTB43 ZNF397 ZNF675	3 interacting genes: APP GRHL3 LMO4
Entrez ID		8543	79977
HPRD ID		09122	10545
Ensembl ID		ENSG00000143013	ENSG00000083307
Uniprot IDs		P61968	B4DL28 Q6ISB3
PDB IDs		2L4Z	5MR7
Enriched GO Terms of Interacting Partners?
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