H2BC12 and HIRA

Number of citations of the paper that reports this interaction (PubMedID 9710638)
32

Data Source:
BioGRID (pull down)

		H2BC12	HIRA
Description		H2B clustered histone 12	histone cell cycle regulator
Image
GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol	HIR Complex Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm PML Body Protein-containing Complex Extracellular Exosome
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Protein Ubiquitination Antibacterial Humoral Response Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Mitotic Sister Chromatid Segregation Osteoblast Differentiation DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Gastrulation Anatomical Structure Morphogenesis Chromatin Silencing At Centromere Regulation Of Chromatin Silencing Muscle Cell Differentiation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		3 interacting genes: CLK1 HIRA SRPK2	14 interacting genes: ASF1A CCNA2 CDK2 H2BC12 H2BC21 H2BC5 H3-3B HIRIP3 HNRNPD NFU1 OGT PAX7 UBE2I UPF1
Entrez ID		85236	7290
HPRD ID		13658	02583
Ensembl ID		ENSG00000197903	ENSG00000100084
Uniprot IDs		A0A024RCL8 O60814	P54198
PDB IDs		2CV5	2I32 5YJE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?