PIGY and ABCB4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PIGY	ABCB4
Description		phosphatidylinositol glycan anchor biosynthesis class Y	ATP binding cassette subfamily B member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Integral Component Of Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome
	Molecular Function	Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Protein Binding ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Phosphatidylcholine-translocating ATPase Activity Ceramide-translocating ATPase Activity
	Biological Process	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1
Drugs
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Bipolar disorder ( 22925353) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alanine transaminase levels ( 29403010) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)
Interacting Genes		3 interacting genes: ABCB4 FBXO7 PIGA	4 interacting genes: HAX1 PIGY PRKAR2B TESK1
Entrez ID		84992	5244
HPRD ID		17492	01371
Ensembl ID		ENSG00000255072	ENSG00000005471
Uniprot IDs		Q3MUY2	P21439
PDB IDs
Enriched GO Terms of Interacting Partners?
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