C1orf94 and HGS

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		C1orf94	HGS
Description		chromosome 1 open reading frame 94	hepatocyte growth factor-regulated tyrosine kinase substrate
Image		No pdb structure
GO Annotations	Cellular Component		Lysosome Endosome Early Endosome Cytosol Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein Domain Specific Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding
	Biological Process		Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Protein Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of MAP Kinase Activity Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways			EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion
Drugs			Citric Acid
Diseases
GWAS		Generalized epilepsy ( 22949513) Lateral ventricle temporal horn volume ( 31530798) Pediatric nonalcoholic steatohepatitis ( 28918882) Sleep duration (short sleep) ( 30846698)	Eye color traits ( 20463881)
Interacting Genes		66 interacting genes: ACTN3 AKAP9 ATRIP ATXN1 BANP BOLA1 BOLL BYSL C1orf109 CARD9 CCHCR1 CCNJL CDKN2D CFAP206 CLK1 CRK CRYBA4 DAB1 DAZAP2 DGCR6 DMRTB1 DOK6 DTX2 FAM168A GCC1 GORASP2 GRB2 GSE1 HGS HNRNPF IPO11 KLHL32 LMO2 MAGED1 MAPK1IP1L MAPK9 MEIS2 MVP NFKBID NGB NR3C1 OAZ3 OIP5 PITX1 PLEKHB2 PRKAG1 PRR20A R3HDM2 RAD51D RBFOX1 RBFOX2 RBM47 RBPMS RFX2 ROR2 SMAP2 TBX6 TENT5D TLE5 TNPO2 TXNDC9 UBQLN4 USO1 VENTX VPS37C YES1	182 interacting genes: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG C1orf94 CASK CBS CCDC103 CCDC114 CCDC136 CCDC33 CDR2 CEP55 CEP57L1 CEP63 CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAJC5 DYDC1 EGFR EHMT2 EPS15 ESRRG EXOC5 EXOC7 EXOC8 FAM168A FANCG FCHSD2 FLOT1 FLOT2 GFAP GFI1B GGA2 GKAP1 GOLGA2 HAP1 HNRNPDL HSFY1 HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KIAA0753 KRT13 KRT15 KRT18 KRT19 KRT31 KRT33B KRT38 KRT40 KRT6A KRTAP26-1 LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD8 NEFL NF2 NMI NPAS2 NUP54 NUP62 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 PMEPA1 PNMA1 POGZ PPP1R16A PPP1R7 PTCD3 RBCK1 RFX6 RHOBTB3 RINT1 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 SS18L1 STAM STAM2 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TEKT1 TFG TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TRAF4 TRAK1 TRAP1 TRIM17 TRIM27 TRIM69 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 ZNF302
Entrez ID		84970	9146
HPRD ID		11310	05085
Ensembl ID		ENSG00000142698	ENSG00000185359
Uniprot IDs		Q6P1W5	A0A0S2Z4R4 O14964
PDB IDs			2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?
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