RGS5 and GNAO1

Number of citations of the paper that reports this interaction (PubMedID 9079700)
32

Data Source:
HPRD (in vivo, in vitro)

		RGS5	GNAO1
Description		regulator of G protein signaling 5	G protein subunit alpha o1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body
	Molecular Function	GTPase Activity GTPase Activator Activity	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Locomotory Behavior Regulation Of Heart Contraction
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Height ( 28552196) Lead levels in blood ( 25820613) Liver enzyme levels (alanine transaminase) ( 24124411) Motion sickness ( 25628336) Response to mTOR inhibitor (rapamycin) ( 24009623)	Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)
Interacting Genes		6 interacting genes: ADRB2 APP GNAI2 GNAI3 GNAO1 GNAQ	34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		8490	2775
HPRD ID		04471	00757
Ensembl ID		ENSG00000143248	ENSG00000087258
Uniprot IDs		A0A024R8X9 O15539	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs		2CRP	6FUF 6G79 6OIK
Enriched GO Terms of Interacting Partners?
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