FKBP6 and CDK5RAP3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		FKBP6	CDK5RAP3
Description		FKBP prolyl isomerase 6	CDK5 regulatory subunit associated protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Identical Protein Binding Hsp90 Protein Binding	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Folding Spermatogenesis Cell Differentiation Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation Positive Regulation Of Viral Genome Replication Meiotic Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Brain Development Cell Proliferation Regulation Of Phosphatase Activity Viral Process Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Meiotic synapsis PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Height ( 31562340) Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		13 interacting genes: ACD CCNK CDK5RAP3 FAM107A GAPDH HSP90AA1 IHO1 LZTS2 MAP3K1 MEOX2 NME7 SUMO1P1 TINF2	12 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4
Entrez ID		8468	80279
HPRD ID		05326	12190
Ensembl ID		ENSG00000077800	ENSG00000108465
Uniprot IDs		A0A3B3IST2 O75344	Q96JB5
PDB IDs		3B7X
Enriched GO Terms of Interacting Partners?
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