AFAP1L2 and SH3PXD2A

Number of citations of the paper that reports this interaction (PubMedID 26446840)
3

Data Source:
BioGRID (pull down, affinity chromatography technology)

		AFAP1L2	SH3PXD2A
Description		actin filament associated protein 1 like 2	SH3 and PX domains 2A
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Podosome Cytosol Cell Junction Cell Projection
	Molecular Function	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity SH2 Domain Binding	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity	In Utero Embryonic Development Superoxide Metabolic Process Extracellular Matrix Organization Positive Regulation Of Catalytic Activity Osteoclast Fusion
Pathways			Invadopodia formation
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Metabolite levels ( 23823483) Systolic blood pressure ( 29212154)	Atrial fibrillation ( 28416818 28416822 29290336 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Intraocular pressure ( 29617998) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Manganese levels ( 26025379) PR interval ( 30046033) Rheumatoid arthritis ( 30891314) Stroke ( 29531354) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensity burden ( 25663218)
Interacting Genes		10 interacting genes: ACD APP ATXN1L POT1 RASA1 SH3PXD2A SRC TERF1 TERF2 TINF2	7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL
Entrez ID		84632	9644
HPRD ID		13902	10228
Ensembl ID		ENSG00000169129	ENSG00000107957
Uniprot IDs		B7Z2Q0 Q8N4X5	B3KPL1 Q5TCZ1
PDB IDs		2COF	2DNU 2EGA 2EGC 2EKH
Enriched GO Terms of Interacting Partners?
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