DOC2B and STXBP1

Number of citations of the paper that reports this interaction (PubMedID 9115738)
49

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DOC2B	STXBP1
Description		double C2 domain beta	syntaxin binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane SNARE Complex Presynapse	Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Calcium-dependent Phospholipid Binding Syntaxin Binding	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding Protein N-terminus Binding
	Biological Process	Protein Localization Positive Regulation Of Vesicle Fusion Positive Regulation Of Insulin Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Spontaneous Neurotransmitter Secretion	Platelet Degranulation Developmental Process Involved In Reproduction Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Negative Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Long-term Synaptic Depression Platelet Aggregation Cellular Response To Interferon-gamma Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Acrosomal Vesicle Exocytosis
Pathways			Regulation of insulin secretion Neurexins and neuroligins
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Whole brain grey matter density ( 31530798)
Interacting Genes		3 interacting genes: DYNLT1 STXBP1 UNC13B	31 interacting genes: APBA1 APBA2 APP C19orf57 CDK5 CDK5R1 DOC2A DOC2B HGS MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SPTBN1 SQSTM1 STOM STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 USO1
Entrez ID		8447	6812
HPRD ID		05196	04235
Ensembl ID		ENSG00000272636	ENSG00000136854
Uniprot IDs		Q14184	P61764
PDB IDs
Enriched GO Terms of Interacting Partners?
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