SLX4 and SLX4IP

Number of citations of the paper that reports this interaction (PubMedID 19596235)
223

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SLX4	SLX4IP
Description		SLX4 structure-specific endonuclease subunit	SLX4 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding 3'-flap Endonuclease Activity	Protein Binding
	Biological Process	Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Positive Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Fasting blood glucose adjusted for BMI ( 28548082) Heel bone mineral density ( 30598549 28869591) Lean body mass ( 28552196) Pulse pressure ( 30224653)
Interacting Genes		9 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A SLX4IP UBC UBE2I	2 interacting genes: SLX4 SUMO2
Entrez ID		84464	128710
HPRD ID		12537	12516
Ensembl ID		ENSG00000188827	ENSG00000149346
Uniprot IDs		Q8IY92	Q5VYV7
PDB IDs		4M7C 4UYI 4ZOU
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?