SLX4IP and SLX4

Number of citations of the paper that reports this interaction (PubMedID 19596235)
223

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SLX4IP	SLX4
Description		SLX4 interacting protein	SLX4 structure-specific endonuclease subunit
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	Protein Binding	Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process		Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Positive Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways			Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Fasting blood glucose adjusted for BMI ( 28548082) Heel bone mineral density ( 30598549 28869591) Lean body mass ( 28552196) Pulse pressure ( 30224653)
Interacting Genes		2 interacting genes: SLX4 SUMO2	9 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A SLX4IP UBC UBE2I
Entrez ID		128710	84464
HPRD ID		12516	12537
Ensembl ID		ENSG00000149346	ENSG00000188827
Uniprot IDs		Q5VYV7	Q8IY92
PDB IDs			4M7C 4UYI 4ZOU
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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