NCK2 and MAGEA6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NCK2	MAGEA6
Description		NCK adaptor protein 2	MAGE family member A6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane Postsynaptic Density	Cellular_component
	Molecular Function	Phosphotyrosine Residue Binding SH3/SH2 Adaptor Activity Protein Binding Cytoskeletal Adaptor Activity Receptor Signaling Complex Scaffold Activity Protein-containing Complex Binding Scaffold Protein Binding	Molecular_function Protein Binding
	Biological Process	Immunological Synapse Formation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Proliferation Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Dendritic Spine Development Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Biological_process
Pathways		Downstream signal transduction Nephrin family interactions Ephrin signaling Activation of RAC1 VEGFA-VEGFR2 Pathway Regulation of cortical dendrite branching
Drugs
Diseases
GWAS		Addiction ( 23533358) Platelet distribution width ( 27863252) Systolic blood pressure in sickle cell anemia ( 24058526)
Interacting Genes		87 interacting genes: ABI1 ABI2 ABI3 ARHGAP32 ATN1 AXIN1 AXL BCL11A CBLB CCDC33 CD3E CHN1 CPSF6 CPSF7 DDR1 DNM1 DOCK1 DOK1 DRAP1 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EFS EGFR EIF3H ERBB2 ERBB3 FAM53C FASLG FCRL2 FGFR1 FXR2 FYB1 HNRNPK HOMEZ HOXC4 ILK IRS1 KHDRBS1 KIAA1217 LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MEOX2 NCKIPSD NPHS1 NR5A1 NTRK2 PAK1 PDGFRB PIK3AP1 PKD1 PKN2 PRR20A PSMD10 PTK2 RASSF7 RBM26 REL SF3B4 SKAP2 SMARCB1 SORBS2 SOS1 SPRY2 SRPK1 SRPK2 SYNPO TCF4 TNR TRIM27 TRIM41 TRIP6 UBC VARS2 VPS37B WAS WASL WBP11 WIPF2 ZBTB7B	40 interacting genes: ACOT7 AKAP9 ANKRD26P1 ATP6V1G1 ATPAF2 BCL7B BET1 CCDC146 CTF1 ELMOD3 EXOC5 FAM214A FRMPD1 GFOD1 HAUS1 HLA-DRB4 IQUB KLHL38 LCORL LIN37 LSM2 MCM7 MED21 MIPOL1 MORN3 NCK2 PDE4D RASSF4 RCOR3 RPL37A S100A14 SH2D4A SNAP47 SNX4 STAMBPL1 STX5 TRIM26 TRIM28 TULP3 TXNDC9
Entrez ID		8440	4105
HPRD ID		05378	02168
Ensembl ID		ENSG00000071051	ENSG00000197172
Uniprot IDs		A0A0S2Z4M6 E7ERP6 O43639	P43360
PDB IDs		1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?
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