RECK and CTH

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RECK	CTH
Description		reversion inducing cysteine rich protein with kazal motifs	cystathionine gamma-lyase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Carbon-sulfur Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity
	Biological Process	Vasculature Development Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity	Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Sulfhydration Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Pyridoxal Phosphate L-Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases			Cystathioninuria
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Brain volume in infants (grey matter) ( 28763065) Seasonality and depression ( 30217971)
Interacting Genes		15 interacting genes: CEP44 CTH KEAP1 KRT40 MEOX2 MMP9 MTNR1B NOTCH2NLA REL SIGMAR1 TCF4 TEKT4 TRIM39 TRIM69 USHBP1	4 interacting genes: GUCD1 NTAQ1 RECK SDCBP2
Entrez ID		8434	1491
HPRD ID		05567	09633
Ensembl ID		ENSG00000122707	ENSG00000116761
Uniprot IDs		A8K9D8 O95980 Q6P9E2	P32929
PDB IDs			2NMP 3COG 3ELP 5EIG 5TSU 5TT2 6NBA
Enriched GO Terms of Interacting Partners?
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