KBTBD7 and CPT1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		KBTBD7	CPT1A
Description		kelch repeat and BTB domain containing 7	carnitine palmitoyltransferase 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Mitochondrion Mitochondrial Outer Membrane Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Molecular_function Protein Binding	Carnitine O-palmitoyltransferase Activity Identical Protein Binding Palmitoleoyltransferase Activity
	Biological Process	MAPK Cascade Biological_process Post-translational Protein Modification	Long-chain Fatty Acid Metabolic Process Glucose Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Circadian Rhythm Carnitine Metabolic Process Response To Organic Cyclic Compound Regulation Of Lipid Metabolic Process Epithelial Cell Differentiation Positive Regulation Of Fatty Acid Beta-oxidation Response To Drug Eating Behavior Regulation Of Insulin Secretion Cellular Response To Fatty Acid
Pathways		Regulation of RAS by GAPs Neddylation Antigen processing: Ubiquitination & Proteasome degradation	RORA activates gene expression PPARA activates gene expression Carnitine metabolism Signaling by Retinoic Acid
Drugs			L-Carnitine Glyburide Perhexiline
Diseases			Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS			Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Lipid metabolism phenotypes ( 22286219) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Obesity-related traits ( 23251661) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes		14 interacting genes: BARD1 BLMH C8orf33 CPT1A DUSP23 GABARAP GABARAPL1 GABARAPL2 HAP1 LRIF1 MAP1LC3B MAP1LC3C NFKBIE PHC2	8 interacting genes: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1 UBC
Entrez ID		84078	1374
HPRD ID		13759	02755
Ensembl ID		ENSG00000120696	ENSG00000110090
Uniprot IDs		Q8WVZ9	A0A024R5F4 B2RAQ8 P50416 Q8WZ48
PDB IDs			2LE3
Enriched GO Terms of Interacting Partners?
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