H4C1 and PBRM1

Number of citations of the paper that reports this interaction (PubMedID 20368734)
25

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, unspecified method)

		H4C1	PBRM1
Description		H4 clustered histone 1	polybromo 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Nuclear Chromosome, Telomeric Region Nucleosome Nuclear Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein-containing Complex Extracellular Exosome	Nuclear Chromosome Nucleoplasm RSC-type Complex SWI/SNF Superfamily-type Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Chromatin Silencing At RDNA Double-strand Break Repair Via Nonhomologous End Joining Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly DNA-templated Transcription, Initiation Telomere Capping Telomere Organization CENP-A Containing Nucleosome Assembly Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing By MiRNA	Mitotic Cell Cycle Nucleosome Disassembly Chromatin Remodeling Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation ATP-dependent Chromatin Remodeling
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Blood protein levels ( 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) General cognitive ability ( 29844566) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Intelligence (MTAG) ( 29326435) Major mood disorders ( 20081856) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		65 interacting genes: ANP32A ANP32B BAZ2A CBX3 CDK1 CDK2 COPS2 CREBBP DPF2 DYRK1A EID1 ELP3 ERCC6 FANCD2 GATAD2A GATAD2B H2AC20 H2BC21 HAT1 HDAC3 HDAC8 HIRIP3 HJURP JADE1 JMJD6 KAT14 KAT2B KAT5 KAT6A KAT7 KAT8 KDM4A KMT5B KMT5C L3MBTL2 MBTD1 MSL2 MSL3 MYB NCOR1 NCOR2 NSD1 NSD3 PAK1 PARP10 PBRM1 PELP1 PHF1 PHF20 PHF8 PRMT5 PRMT7 PRMT8 PTMA SETD7 SIRT7 TAF1A TAF1B TBL1X THAP7 TLE3 TRIM29 UCHL5 WBP2 ZMYND8	9 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 PTS SMARCA4 ZDHHC17 ZNF512B
Entrez ID		8359	55193
HPRD ID		04157	07302
Ensembl ID		ENSG00000278637	ENSG00000163939
Uniprot IDs		B2R4R0 P62805	Q86U86
PDB IDs		1ZKK 2BQZ 2CV5 2IG0 2KWN 2KWO 2LVM 2QQS 2RJE 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3IJ1 3JPX 3NQJ 3NQU 3O36 3QBY 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3WTP 3X1S 3X1T 3X1U 3X1V 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4M38 4N3W 4N4F 4QUT 4QUU 4QYD 4U9W 4YM5 4YM6 4YY6 4YYD 4YYG 4YYH 4YYI 4YYJ 4YYK 4YYM 4YYN 4Z2M 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5BNV 5BNX 5BO0 5C3I 5CPI 5CPJ 5CPK 5FA5 5FFW 5FWE 5GSE 5GSU 5GT0 5GT3 5GTC 5GXQ 5JA4 5JRG 5KDM 5TEG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5YE3 5YE4 5Z23 5Z30 5ZBX 5ZGC 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACP 6BUZ 6C0W 6E0C 6E0P 6FML 6HKT 6HTS 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6MLC 6MUO 6MUP 6O1D 6R0C 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6RNY 6SE0 6SE6 6SEE 6SEF 6SEG 6UHD	2KTB 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID
Enriched GO Terms of Interacting Partners?
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