BAP1 and UBE2O

Number of citations of the paper that reports this interaction (PubMedID 24703950)
50

Data Source:
BioGRID (biochemical, affinity chromatography technology, enzymatic study, pull down)

		BAP1	UBE2O
Description		BRCA1 associated protein 1	ubiquitin conjugating enzyme E2 O
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PR-DUB Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Thiol-dependent Ubiquitinyl Hydrolase Activity	RNA Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Proliferation Response To Inorganic Substance Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Macrophage Homeostasis Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Endopeptidase Activity Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Protein K63-linked Ubiquitination
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mitochondrial DNA levels ( 25240745)
Interacting Genes		27 interacting genes: BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 IGF1R ITPR3 KLF5 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	16 interacting genes: APPL1 BAP1 CPNE1 CPNE2 CPNE4 HEXIM1 ITCH MAF MDM2 PRKN RNF10 RNF31 SHBG TRIM27 UBC UBE2D3
Entrez ID		8314	63893
HPRD ID		04366	10928
Ensembl ID		ENSG00000163930	ENSG00000175931
Uniprot IDs		A0A024R305 F8W6N3 Q92560	Q9C0C9
PDB IDs
Enriched GO Terms of Interacting Partners?
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