UBE2O and HEXIM1

Number of citations of the paper that reports this interaction (PubMedID 29845934)
4

Data Source:
BioGRID (enzymatic study)

		UBE2O	HEXIM1
Description		ubiquitin conjugating enzyme E2 O	HEXIM P-TEFb complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Endopeptidase Activity Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Protein K63-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Heart Development Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mitochondrial DNA levels ( 25240745)	Asthma ( 31619474) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		16 interacting genes: APPL1 BAP1 CPNE1 CPNE2 CPNE4 HEXIM1 ITCH MAF MDM2 PRKN RNF10 RNF31 SHBG TRIM27 UBC UBE2D3	10 interacting genes: CCNT1 CCNT2 CDK9 EGFR ESR1 RELA RN7SK TERF1 TERF2 UBE2O
Entrez ID		63893	10614
HPRD ID		10928	09544
Ensembl ID		ENSG00000175931	ENSG00000186834
Uniprot IDs		Q9C0C9	O94992
PDB IDs			2GD7 3S9G
Enriched GO Terms of Interacting Partners?
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