CAST and PPFIA3

Number of citations of the paper that reports this interaction (PubMedID 12923177)
60

Data Source:
HPRD (in vitro, two hybrid)

		CAST	PPFIA3
Description		calpastatin	PTPRF interacting protein alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Membrane	Acrosomal Vesicle Cytosol Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Epididymosome Glutamatergic Synapse
	Molecular Function	RNA Binding Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cadherin Binding	Protein Binding
	Biological Process	Inhibition Of Cysteine-type Endopeptidase Activity Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Neurotransmitter Secretion Glutamate Secretion Synaptic Vesicle Docking Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs		Calcium Artenimol
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Blood protein levels ( 28240269) Body mass index ( 26426971) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		10 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4	11 interacting genes: CAST ERC2 GIT1 PPFIA1 PPFIA2 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS PTPRU
Entrez ID		831	8541
HPRD ID		00233	04393
Ensembl ID		ENSG00000153113	ENSG00000177380
Uniprot IDs		B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9	O75145
PDB IDs
Enriched GO Terms of Interacting Partners?
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