PICALM and FCHO1

Number of citations of the paper that reports this interaction (PubMedID 27237791)
24

Data Source:
BioGRID (pull down)

		PICALM	FCHO1
Description		phosphatidylinositol binding clathrin assembly protein	FCH and mu domain containing endocytic adaptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cell Surface Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Intrinsic Component Of Membrane Vesicle Presynaptic Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Endosome To Plasma Membrane Transport Vesicle Neurofibrillary Tangle Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle
	Molecular Function	SNARE Binding Amyloid-beta Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Rab GTPase Binding Clathrin Binding Clathrin Heavy Chain Binding Cadherin Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding Cytoskeletal Protein Binding AP-2 Adaptor Complex Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Vesicle Budding From Membrane Axonogenesis Learning Or Memory Negative Regulation Of Gene Expression Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Cargo Loading Into Vesicle Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Dendrite Morphogenesis Iron Ion Homeostasis Membrane Organization Protein-containing Complex Assembly Clathrin-dependent Endocytosis Modulation Of Age-related Behavioral Decline Regulation Of Vesicle Size Membrane Bending Amyloid-beta Clearance By Transcytosis Positive Regulation Of Neuron Death Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Clathrin-coated Pit Assembly Negative Regulation Of Protein Localization To Cell Surface	Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 19734902 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Chronic obstructive pulmonary disease ( 30804561) Family history of Alzheimer's disease ( 30617256) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Platelet count ( 27863252) Tourette syndrome ( 22889924)	Coronary artery disease ( 29212778)
Interacting Genes		14 interacting genes: AP2A1 CASP3 CASP8 CLTC CLTCL1 CRX DDIT3 EHD2 FCHO1 ITSN1 PELI2 PLCG1 RBPMS SMURF1	17 interacting genes: ACVR1 APP DAB2 DNAJC5 EPS15 EPS15L1 EXOSC5 GDF15 ITSN1 LGALS14 NCK1 PICALM PTK6 SMURF1 SRPK2 ZBTB16 ZNF688
Entrez ID		8301	23149
HPRD ID		04320	16887
Ensembl ID		ENSG00000073921	ENSG00000130475
Uniprot IDs		A0A024R5L7 A0A024R5P1 Q13492	A0A0C3SFZ9 B7ZAZ3 O14526
PDB IDs
Enriched GO Terms of Interacting Partners?
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