FCHO1 and GDF15

		FCHO1	GDF15
Description		FCH and mu domain containing endocytic adaptor 1	growth differentiation factor 15
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Cytoskeletal Protein Binding AP-2 Adaptor Complex Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		17 interacting genes: ACVR1 APP DAB2 DNAJC5 EPS15 EPS15L1 EXOSC5 GDF15 ITSN1 LGALS14 NCK1 PICALM PTK6 SMURF1 SRPK2 ZBTB16 ZNF688	16 interacting genes: ALOX5AP BORCS8-MEF2B C19orf57 COPE EHF FCHO1 HOMER3 IL27RA MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1
Entrez ID		23149	9518
HPRD ID		16887	05608
Ensembl ID		ENSG00000130475	ENSG00000130513
Uniprot IDs		A0A0C3SFZ9 B7ZAZ3 O14526	Q99988
PDB IDs			5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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