CANX and IFNGR1

Number of citations of the paper that reports this interaction (PubMedID 8136357)
20

Data Source:
HPRD (in vivo)

		CANX	IFNGR1
Description		calnexin	interferon gamma receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Protein-containing Complex Melanosome Neuronal Cell Body Dendritic Spine Mitochondria-associated ER Membrane Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Active Zone Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Unfolded Protein Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Protein Folding In Endoplasmic Reticulum Synaptic Vesicle Endocytosis Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Clathrin-dependent Endocytosis	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Tumor Necrosis Factor Secretion
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling
Drugs		Antihemophilic factor, human recombinant Tenecteplase Calcium Citrate Calcium Phosphate	Interferon gamma-1b
Diseases			Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Daytime sleep phenotypes ( 27126917) Myeloid white cell count ( 27863252) Resting heart rate ( 24680774) White blood cell count ( 27863252)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)
Interacting Genes		44 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 NUTF2 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	9 interacting genes: CANX IFNG IFNGR2 JAK1 JAK2 PTPN11 RAC1 SOCS1 STAT1
Entrez ID		821	3459
HPRD ID		00252	00127
Ensembl ID		ENSG00000127022	ENSG00000027697
Uniprot IDs		P27824	A0A0S2Z3Y2 A0A2R8Y4U4 P15260
PDB IDs			1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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