IFNGR1 and IFNGR2

Number of citations of the paper that reports this interaction (PubMedID 7673114)
31

Data Source:
HPRD (in vivo)

		IFNGR1	IFNGR2
Description		interferon gamma receptor 1	interferon gamma receptor 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity
	Biological Process	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Tumor Necrosis Factor Secretion	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling
Drugs		Interferon gamma-1b	Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency	Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		9 interacting genes: CANX IFNG IFNGR2 JAK1 JAK2 PTPN11 RAC1 SOCS1 STAT1	8 interacting genes: ANXA5 CAMK2D DNAJA3 IFNG IFNGR1 JAK2 NR3C1 RPL37A
Entrez ID		3459	3460
HPRD ID		00127	00956
Ensembl ID		ENSG00000027697	ENSG00000159128
Uniprot IDs		A0A0S2Z3Y2 A0A2R8Y4U4 P15260	A8K881 E7EUY1 P38484
PDB IDs		1FG9 1FYH 1JRH 6E3K 6E3L	5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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