GDF5 and ACVR2A

Number of citations of the paper that reports this interaction (PubMedID 8702914)
59

Data Source:
HPRD (in vivo)

		GDF5	ACVR2A
Description		growth differentiation factor 5	activin A receptor type 2A
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity BMP Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding BMP Receptor Activity
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Ossification Involved In Bone Remodeling Positive Regulation Of Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Chondroblast Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus
Pathways		Molecules associated with elastic fibres	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs		Isopropyl Alcohol	Sotatercept
Diseases		Brachydactyly, including: Brachydactyly type C; Angel shaped phalangoepiphyseal dysplasia (ASPED) Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome Grebe dysplasia; Acromesomelic dysplasia Hunter-Thompson type Fibular hypoplasia and complex brachydactyly; DuPan syndrome
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Femoral neck size ( 31053729) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391950 18391951 18391952 20189936) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Infant length ( 25281659) Intertrochanteric region size ( 31053729) Joint mobility (Beighton score) ( 27182965) Knee osteoarthritis ( 30664745 30374069) Knee pain ( 31482140) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Spine bone size ( 31053729) Trochanter size ( 31053729) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Weight ( 28552196)	Adventurousness ( 30643258) Arterial stiffness index ( 31235810) Asthma (adult onset) ( 31036433) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Cerebrospinal T-tau levels ( 28247064) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Feeling tense ( 29500382) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Loneliness (MTAG) ( 29970889) Neutrophil percentage of granulocytes ( 27863252) Photic sneeze reflex ( 30899065) Response to statin therapy ( 20339536) Urate levels ( 23263486) White blood cell count (basophil) ( 27863252)
Interacting Genes		8 interacting genes: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1	23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 DAXX ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TCTEX1D4 TDGF1 TGFBR3
Entrez ID		8200	92
HPRD ID		03092	00025
Ensembl ID		ENSG00000125965	ENSG00000121989
Uniprot IDs		F1T0J1 P43026	P27037
PDB IDs		1WAQ 2BHK 3EVS 3QB4 5HK5	3Q4T 3SOC 4ASX 5NH3
Enriched GO Terms of Interacting Partners?
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