CAMP and FPR2

Number of citations of the paper that reports this interaction (PubMedID 11015447)
308

Data Source:
HPRD (in vivo)

		CAMP	FPR2
Description		cathelicidin antimicrobial peptide	formyl peptide receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Specific Granule Lumen Specific Granule Extracellular Exosome Tertiary Granule Lumen	Cell Cytoplasm Plasma Membrane Integral Component Of Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Lipopolysaccharide Binding	Amyloid-beta Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Signaling Receptor Activity Cargo Receptor Activity
	Biological Process	Innate Immune Response In Mucosa Antimicrobial Humoral Response Antibacterial Humoral Response Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Superoxide Anion Generation Defense Response To Bacterium Neutrophil Degranulation Positive Regulation Of Innate Immune Response Astrocyte Activation Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Chemotaxis Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis Cellular Response To Amyloid-beta
Pathways		Neutrophil degranulation Antimicrobial peptides	G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Neutrophil degranulation
Drugs		Selenocysteine
Diseases
GWAS		Blood protein levels ( 30072576 28240269)	Alopecia areata ( 25608926) Multiple sclerosis ( 31604244 24076602) Tourette syndrome ( 30818990)
Interacting Genes		8 interacting genes: CTSG ELANE FPR2 GPX1 LBP MAPK8 PRTN3 RHOA	2 interacting genes: CAMP ERC1
Entrez ID		820	2358
HPRD ID		02722	00647
Ensembl ID		ENSG00000164047	ENSG00000171049
Uniprot IDs		A0A384NPR0 J3KNB4 P49913	A0A024R4P3 P25090
PDB IDs		2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX
Enriched GO Terms of Interacting Partners?
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