SHARPIN and YOD1

Number of citations of the paper that reports this interaction (PubMedID 28244869)
5

Data Source:
BioGRID (two hybrid)

		SHARPIN	YOD1
Description		SHANK associated RH domain interactor	YOD1 deubiquitinase
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Cell Junction Dendrite LUBAC Complex	Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding	Nucleic Acid Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Macroautophagy Protein Deubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins	Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Systolic blood pressure ( 28234671)
Interacting Genes		16 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 PPIL3 SHANK1 SHANK2 TRAF1 TXN2 UBC YOD1	12 interacting genes: BIRC3 NEDD4 RIPK1 SHARPIN SNCA TRIM54 TRIM55 TRIM63 UBC UBE3A USP15 USP21
Entrez ID		81858	55432
HPRD ID		15463	10312
Ensembl ID		ENSG00000179526	ENSG00000180667
Uniprot IDs		Q6PJD5 Q9H0F6	Q5VVQ6
PDB IDs		4EMO 5X0W	4BOQ 4BOS 4BOZ
Enriched GO Terms of Interacting Partners?
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