YOD1 and SHARPIN

Number of citations of the paper that reports this interaction (PubMedID 28244869)
5

Data Source:
BioGRID (two hybrid)

		YOD1	SHARPIN
Description		YOD1 deubiquitinase	SHANK associated RH domain interactor
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Cell Junction Dendrite LUBAC Complex
	Molecular Function	Nucleic Acid Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Macroautophagy Protein Deubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		Ovarian tumor domain proteases	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		Systolic blood pressure ( 28234671)	Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		12 interacting genes: BIRC3 NEDD4 RIPK1 SHARPIN SNCA TRIM54 TRIM55 TRIM63 UBC UBE3A USP15 USP21	16 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 PPIL3 SHANK1 SHANK2 TRAF1 TXN2 UBC YOD1
Entrez ID		55432	81858
HPRD ID		10312	15463
Ensembl ID		ENSG00000180667	ENSG00000179526
Uniprot IDs		Q5VVQ6	Q6PJD5 Q9H0F6
PDB IDs		4BOQ 4BOS 4BOZ	4EMO 5X0W
Enriched GO Terms of Interacting Partners?
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