MED25 and HCFC1

Number of citations of the paper that reports this interaction (PubMedID 14983011)
61

Data Source:
HPRD (in vivo, in vitro)

		MED25	HCFC1
Description		mediator complex subunit 25	host cell factor C1
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GO Annotations	Cellular Component	Nucleoplasm Mediator Complex Nuclear Transcription Factor Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Membrane Axon Dendrite Protein-containing Complex Neuronal Cell Body Set1C/COMPASS Complex SAGA-type Complex MLL1 Complex
	Molecular Function	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Protein Binding, Bridging Activating Transcription Factor Binding Identical Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Cadherin Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Remodeling Regulation Of Transcription, DNA-templated Mitochondrion Organization Cell Cycle Positive Regulation Of Gene Expression Protein Deubiquitination Release From Viral Latency Regulation Of Protein Complex Assembly Histone H4 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Protein Stabilization Cellular Response To Organic Cyclic Compound
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood trace element (Se levels) ( 23720494)	Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)
Interacting Genes		14 interacting genes: CDK8 CREBBP CTDP1 HCFC1 MED1 MED15 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA	32 interacting genes: ASF1B CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIN3A SP1 TAF9 THAP11 THAP7 YY1 ZBTB17
Entrez ID		81857	3054
HPRD ID		14380	02061
Ensembl ID		ENSG00000104973	ENSG00000172534
Uniprot IDs		M0QZQ2 Q71SY5	A6NEM2 P51610
PDB IDs		2KY6 2L23 2L6U 2XNF	4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5
Enriched GO Terms of Interacting Partners?
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