SNX27 and HLCS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SNX27	HLCS
Description		sorting nexin 27	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Endosome Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex	Chromatin Nuclear Lamina Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS		Body mass index ( 26426971)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Seasonality and depression ( 30217971)
Interacting Genes		10 interacting genes: AKT2 APP DGKZ HLCS PNPLA3 PTEN RPS6KA1 SELP SLC2A1 VPS26A	4 interacting genes: ACACB DDX52 POT1 SNX27
Entrez ID		81609	3141
HPRD ID		11591	08360
Ensembl ID		ENSG00000143376	ENSG00000159267
Uniprot IDs		A0A2R8Y8A7 Q96L92	P50747
PDB IDs		4HAS 5ZN9 6SAK
Enriched GO Terms of Interacting Partners?
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