HLCS

Description		holocarboxylase synthetase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Seasonality and depression ( 30217971)
Interacting Genes		4 interacting genes: ACACB DDX52 POT1 SNX27
Entrez ID		3141
HPRD ID		08360
Ensembl ID		ENSG00000159267
Uniprot IDs		P50747
PDB IDs
Enriched GO Terms of Interacting Partners?
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