CFHR5 and CREB3L1

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		CFHR5	CREB3L1
Description		complement factor H related 5	cAMP responsive element binding protein 3 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Protein-containing Complex	Nuclear Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Heterodimerization Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding SMAD Binding
	Biological Process	Complement Activation, Alternative Pathway Regulation Of Complement Activation Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Multicellular Organism Development Negative Regulation Of Gene Expression Viral Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Regulation of Complement cascade	CREB3 factors activate genes
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Asthma ( 29273806) Blood protein levels ( 30072576 29875488 28240269) Lupus nephritis in systemic lupus erythematosus ( 24925725) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Systolic blood pressure ( 30578418)
Interacting Genes		4 interacting genes: C3 CREB3 CREB3L1 LMNA	30 interacting genes: C5 CD99L2 CFHR5 CREB3 CREB3L3 CREM CYBC1 DDIT3 FAM3C FXYD3 FXYD6 GPR25 HIF1A JAGN1 MFSD5 NRM PGAP2 PGRMC1 PLN PLP1 PRKAB2 RUNX1T1 SLC30A8 SLC35B4 TMEM11 TMEM128 TMEM147 TMEM218 TMEM234 TSPO
Entrez ID		81494	90993
HPRD ID		06508	16751
Ensembl ID		ENSG00000134389	ENSG00000157613
Uniprot IDs		Q9BXR6	B2RA75 Q96BA8
PDB IDs
Enriched GO Terms of Interacting Partners?
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