ACTN4 and CAMK2B

Number of citations of the paper that reports this interaction (PubMedID 11160423)
68

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		ACTN4	CAMK2B
Description		actinin alpha 4	calcium/calmodulin dependent protein kinase II beta
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Cytosol Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Nuclear Body Z Disc Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Cell Junction Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Ion Channel Binding Protein N-terminus Binding Actin Filament Binding	Actin Binding Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Platelet Degranulation Protein Transport Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Bicellular Tight Junction Assembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Protein Localization To Bicellular Tight Junction Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Nucleic Acid-templated Transcription	Protein Phosphorylation Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Regulation Of Neuron Migration
Pathways		Platelet degranulation Nephrin family interactions	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants
Drugs			[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Heart rate ( 23583979) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418)
Interacting Genes		50 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TXN UCHL5 USP6NL VDR	38 interacting genes: ACOT7 ACTN4 AP5B1 ATXN1 CAMK2D CAMK2N2 CCM2L COL4A3 ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRTAP10-11 KRTAP19-5 KRTAP19-7 MAD2L2 MED18 MGAT5B MORF4L1 MRPL11 MVP PHKB PLCB3 POP5 RAP2B RBFOX2 RBPMS RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TTC5 YWHAB ZBTB32
Entrez ID		81	816
HPRD ID		05222	12127
Ensembl ID		ENSG00000130402	ENSG00000058404
Uniprot IDs		A0A0S2Z3G9 O43707	A4D2J9 B7Z1Z6 Q13554
PDB IDs		1WLX 1YDI 2R0O	3BHH
Enriched GO Terms of Interacting Partners?
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