SLC19A3 and TAB2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SLC19A3	TAB2
Description		solute carrier family 19 member 3	TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Thiamine Transmembrane Transporter Activity	Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Thiamine-containing Compound Metabolic Process Transmembrane Transport Thiamine Transmembrane Transport	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Heart Development Negative Regulation Of Autophagy Response To Lipopolysaccharide Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		Vitamin B1 (thiamin) metabolism	Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs		L-Cysteine
Diseases
GWAS		Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Obesity-related traits ( 23251661)	Breast cancer ( 22383897 29059683) Diverticulitis ( 28585551) Dupuytren's disease ( 28886342 21732829)
Interacting Genes		4 interacting genes: C3orf38 CREB3 CREB3L4 TAB2	34 interacting genes: APP CST9L EIF2AK2 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 IKBKB IKBKG IRAK1 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TRAF2 TRAF3IP1 TRAF6 UBC UBE2I VIM XIAP YWHAZ ZBTB16
Entrez ID		80704	23118
HPRD ID		07311	05483
Ensembl ID		ENSG00000135917	ENSG00000055208
Uniprot IDs		Q9BZV2	B4DIR9 Q9NYJ8
PDB IDs			2DAE 2WWZ 2WX0 2WX1
Enriched GO Terms of Interacting Partners?
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