TAB2 and NR2C2

Number of citations of the paper that reports this interaction (PubMedID 14633987)
92

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		TAB2	NR2C2
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 2	nuclear receptor subfamily 2 group C member 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Signaling Receptor Activity Sequence-specific DNA Binding
	Biological Process	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Heart Development Negative Regulation Of Autophagy Response To Lipopolysaccharide Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Cell Differentiation Positive Regulation Of Embryonic Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Breast cancer ( 22383897 29059683) Diverticulitis ( 28585551) Dupuytren's disease ( 28886342 21732829)	Alcohol and nicotine co-dependence ( 22488850)
Interacting Genes		34 interacting genes: APP CST9L EIF2AK2 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 IKBKB IKBKG IRAK1 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TRAF2 TRAF3IP1 TRAF6 UBC UBE2I VIM XIAP YWHAZ ZBTB16	23 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RPL36 RXRB TAB1 TAB2 TRAF2
Entrez ID		23118	7182
HPRD ID		05483	03253
Ensembl ID		ENSG00000055208	ENSG00000177463
Uniprot IDs		B4DIR9 Q9NYJ8	F2YGU2 P49116
PDB IDs		2DAE 2WWZ 2WX0 2WX1	3P0U
Enriched GO Terms of Interacting Partners?
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