OPA3 and NGLY1

		OPA3	NGLY1
Description		outer mitochondrial membrane lipid metabolism regulator OPA3	N-glycanase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Cytoplasm Cytosol
	Molecular Function		Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Visual Perception Regulation Of Lipid Metabolic Process Regulation Of Growth Response To Stimulus Neuromuscular Process Mitochondrion Morphogenesis	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases		3-Methylglutaconic aciduria (MGCA) Autosomal dominant optic atrophy (DOA); Kjer's optic neuropathy
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Depression and alcohol dependence ( 22064162)
Interacting Genes		6 interacting genes: APP KDM1A NGLY1 PRMT6 SUV39H1 UBC	19 interacting genes: APP FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NSFL1C OPA3 PROC RAD23A RAD23B SH3BP1 SRPK2 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP
Entrez ID		80207	55768
HPRD ID		05956	10118
Ensembl ID		ENSG00000125741	ENSG00000151092
Uniprot IDs		B4DK77 Q9H6K4	Q96IV0
PDB IDs			2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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