NGLY1 and TRAFD1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

		NGLY1	TRAFD1
Description		N-glycanase 1	TRAF-type zinc finger domain containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding	Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation	Negative Regulation Of Innate Immune Response
Pathways		N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 26426971 25673413) Coffee consumption ( 29367735) Hemoglobin ( 19862010) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300)
Interacting Genes		19 interacting genes: APP FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NSFL1C OPA3 PROC RAD23A RAD23B SH3BP1 SRPK2 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP	4 interacting genes: HTT NGLY1 TRAF6 UBC
Entrez ID		55768	10906
HPRD ID		10118	10994
Ensembl ID		ENSG00000151092	ENSG00000135148
Uniprot IDs		Q96IV0	A0A024RBK4 O14545
PDB IDs		2CCQ 2CM0	2D9K
Enriched GO Terms of Interacting Partners?
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