THOC7 and MED8

Number of citations of the paper that reports this interaction (PubMedID 12584197)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		THOC7	MED8
Description		THO complex 7	mediator complex subunit 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	RNA Binding Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Coregulator Activity Protein Binding
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing Viral MRNA Export From Host Cell Nucleus	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 28991256 25056061 29483656 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)	Feeling worry ( 29500382) Schizophrenia ( 28991256)
Interacting Genes		7 interacting genes: CHD3 CKAP4 GOT2 MED22 MED8 NIF3L1 THOC5	31 interacting genes: APP ARRB2 CCNC CDK8 CTDP1 ELOC HSPB3 KRT40 MED1 MED11 MED12 MED17 MED19 MED20 MED22 MED25 MED26 MED27 MED28 MED30 MED31 MED6 MED7 MED9 PEX14 PHYHIP PNMA1 SNTA1 THOC7 UBALD1 USP49
Entrez ID		80145	112950
HPRD ID		17632	06991
Ensembl ID		ENSG00000163634	ENSG00000159479
Uniprot IDs		A0A024R332 Q6I9Y2	Q96G25
PDB IDs
Enriched GO Terms of Interacting Partners?
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