MZT2B and CDC37

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MZT2B	CDC37
Description		mitotic spindle organizing protein 2B	cell division cycle 37, HSP90 cochaperone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Spindle Cytosol Gamma-tubulin Ring Complex	Cytoplasm Cytosol Extracellular Exosome Chaperone Complex HSP90-CDC37 Chaperone Complex
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding
	Biological Process		Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Posttranscriptional Regulation Of Gene Expression ERBB2 Signaling Pathway Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Downregulation of ERBB2 signaling Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS			Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 21833088)
Interacting Genes		3 interacting genes: CDC37 SETDB1 SRPK2	75 interacting genes: A2M AKT1 APOE APP AR BTBD10 C19orf44 CC2D1A CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CYP2C9 DCTN1 DEAF1 ECSIT EIF2AK1 EIF2S1 ELAVL3 EXOSC1 FBXL12 FBXW4 GCDH GCH1 HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IMMT LONP1 LOXL4 LUC7L2 MAP3K14 MAP3K3 MTOR MZT2B NCOA5 NOS3 NR2C2 OGA PPHLN1 PPP5C PRAM1 PRDX2 PRMT1 PSME1 PTGES3 RAD23A RAF1 RNF32 RPS15A SAFB SNX5 SPTBN4 SRC STAMBPL1 STIP1 STK11 TBK1 UBE2I ZNF205 ZNF235 ZNF266 ZNF667
Entrez ID		80097	11140
HPRD ID		07857	05456
Ensembl ID		ENSG00000152082	ENSG00000105401
Uniprot IDs		B8ZZ87 Q6NZ67	A0A024R7B7 Q16543
PDB IDs			1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE
Enriched GO Terms of Interacting Partners?
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