CDC37 and GCDH

Number of citations of the paper that reports this interaction (PubMedID 21163940)
33

Data Source:
BioGRID (two hybrid)

		CDC37	GCDH
Description		cell division cycle 37, HSP90 cochaperone	glutaryl-CoA dehydrogenase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Chaperone Complex HSP90-CDC37 Chaperone Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding	Fatty-acyl-CoA Binding Glutaryl-CoA Dehydrogenase Activity Glutaryl-CoA Hydrolase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Posttranscriptional Regulation Of Gene Expression ERBB2 Signaling Pathway Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization	Lysine Catabolic Process Tryptophan Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Fatty-acyl-CoA Biosynthetic Process
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Downregulation of ERBB2 signaling Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants	Lysine catabolism
Drugs			Flavin adenine dinucleotide S-4-Nitrobutyryl-Coa
Diseases			Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 21833088)	Blood metabolite levels ( 24816252) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular hemoglobin ( 27863252 19862010) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		75 interacting genes: A2M AKT1 APOE APP AR BTBD10 C19orf44 CC2D1A CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CYP2C9 DCTN1 DEAF1 ECSIT EIF2AK1 EIF2S1 ELAVL3 EXOSC1 FBXL12 FBXW4 GCDH GCH1 HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IMMT LONP1 LOXL4 LUC7L2 MAP3K14 MAP3K3 MTOR MZT2B NCOA5 NOS3 NR2C2 OGA PPHLN1 PPP5C PRAM1 PRDX2 PRMT1 PSME1 PTGES3 RAD23A RAF1 RNF32 RPS15A SAFB SNX5 SPTBN4 SRC STAMBPL1 STIP1 STK11 TBK1 UBE2I ZNF205 ZNF235 ZNF266 ZNF667	11 interacting genes: A2M APOE CDC37 ECSIT EXOC6 MAST1 NOS3 PSEN1 PSEN2 RNF32 THTPA
Entrez ID		11140	2639
HPRD ID		05456	01977
Ensembl ID		ENSG00000105401	ENSG00000105607
Uniprot IDs		A0A024R7B7 Q16543	A0A024R7F9 Q92947
PDB IDs		1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE	1SIQ 1SIR 2R0M 2R0N
Enriched GO Terms of Interacting Partners?
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