DSN1 and PIK3R3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		DSN1	PIK3R3
Description		DSN1 component of MIS12 kinetochore complex	phosphoinositide-3-kinase regulatory subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Spindle Pole Condensed Nuclear Chromosome Inner Kinetochore Fibrillar Center Extracellular Region Nucleoplasm Nucleolus Cytosol Nuclear Body Azurophil Granule Lumen	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protein Binding	Phosphotyrosine Residue Binding Protein Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Mitotic Sister Chromatid Segregation Neutrophil Degranulation Cell Division	Positive Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Neutrophil degranulation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL
Drugs			Isoprenaline SF1126
Diseases
GWAS		Factor VII activity ( 30642921)	Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Breast cancer ( 29059683) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Sodium levels ( 29403010) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		11 interacting genes: AIMP2 APP CBX3 CBX5 KNL1 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT	81 interacting genes: ABCB6 ABL2 AMBP ANKS1A AUNIP AXL BRK1 BTK CAMK1 CCDC14 CCDC33 CEP126 CEP19 CLNK CRBN CRK DARS1 DCAF8 DRAP1 DSN1 E2F6 EGFR ERBB2 ERBB3 ESR1 FBN3 FER FGB FOXO1 FSD2 FYN GC HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 KARS1 KHDRBS1 KLC2 KLF15 KMT2B L3MBTL3 LNX2 LUC7L2 MBIP MECOM MICAL1 MTF2 NCK1 ORM1 PACRGL PCDHB5 PDGFRB PELO PIK3CA PLB1 PPARA PSME1 QARS1 RB1 RING1 SERF1A SOCS6 SRC STAT3 TEC TERF2 TNNC2 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 ZMAT1 ZNF281 ZNF451
Entrez ID		79980	8503
HPRD ID		16455	05831
Ensembl ID		ENSG00000149636	ENSG00000117461
Uniprot IDs		A8K3X3 Q9H410	B4DXM8 Q68CY7 Q7Z3W2 Q8N381 Q92569
PDB IDs		5LSI 5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?