CEP76 and CAPN3

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		CEP76	CAPN3
Description		centrosomal protein 76	calpain 3
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Protein-containing Complex	Intracellular Cell Nucleus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein-containing Complex
	Molecular Function	Protein Binding	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Sodium Ion Binding Titin Binding Ligase Regulator Activity Molecular Adaptor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Centriole Replication Ciliary Basal Body-plasma Membrane Docking	Proteolysis Apoptotic Process Muscle Organ Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Protein Catabolic Process Myofibril Assembly Protein Destabilization Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Regulation Of Catalytic Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development Protein-containing Complex Assembly G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis Calcium-dependent Self Proteolysis
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Degradation of the extracellular matrix
Drugs
Diseases			Calpainopathy; Limb-girdle muscular dystrophy 2A (LGMD2A) Limb-girdle muscular dystrophy (LGMD)
GWAS			Fibrinogen levels ( 28107422 26561523) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565)
Interacting Genes		55 interacting genes: AKAP7 AKT1 BANP C22orf39 CABP5 CAPN3 CCDC92 CCNK CIR1 COIL CRYBA4 CSNK1G1 CUTC DCTD DZIP1L EAF1 EP400P1 FAM90A1 GDAP2 GFAP HSPB7 ILVBL KIAA1143 KIFBP KLHDC4 LATS1 MAGEA11 MBD3 MLH1 NHLRC2 NME5 PAICS PARD6B PIN1 PLCB1 POM121 RADIL RNF128 RPL9 SALL2 SH2D4A SINHCAF STK26 TBC1D27P THRA TOB2 TSPOAP1 TSSC4 TTC21A TUFT1 TXNDC9 WDFY3 ZBTB24 ZMAT2 ZNF85	9 interacting genes: CEP76 DYSF FLNC NECAB2 NTAQ1 OSGIN1 TFCP2 TTN YWHAQ
Entrez ID		79959	825
HPRD ID		12694	00255
Ensembl ID		ENSG00000101624	ENSG00000092529
Uniprot IDs		B4DP81 Q8TAP6	A0A0S2Z3E1 P20807
PDB IDs			1Y9V 4OKH 6BDT 6BGP 6BJD 6BKJ
Enriched GO Terms of Interacting Partners?
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