GSDMD and KCTD6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GSDMD	KCTD6
Description		gasdermin D	potassium channel tetramerization domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol Plasma Membrane Specific Granule Lumen NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cytosol M Band
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding	Protein Binding Ankyrin Binding Identical Protein Binding Cullin Family Protein Binding
	Biological Process	Inflammatory Response Cellular Response To Extracellular Stimulus Pore Formation In Membrane Of Other Organism Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Pore Complex Assembly Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Pyroptosis	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Growth Post-translational Protein Modification Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization
Pathways		Neutrophil degranulation	RUNX1 regulates estrogen receptor mediated transcription Neddylation Estrogen-dependent gene expression Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Schizophrenia ( 31268507)	Hepcidin/transferrin saturation ratio ( 27846281) Systemic lupus erythematosus ( 28714469) vWF levels ( 30586737)
Interacting Genes		2 interacting genes: KCTD6 MFHAS1	17 interacting genes: ACTN1 ACTN3 ANK1 C8orf33 CDC23 CTNND1 EHHADH FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 PPIG PRPF31 SDCBP ZCCHC10
Entrez ID		79792	200845
HPRD ID		11014	13769
Ensembl ID		ENSG00000104518	ENSG00000168301
Uniprot IDs		P57764	Q8NC69
PDB IDs		5NH1 5WQT 6AO4 6N9O
Enriched GO Terms of Interacting Partners?
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