KCTD6 and GSDMD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KCTD6	GSDMD
Description		potassium channel tetramerization domain containing 6	gasdermin D
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol M Band	Extracellular Region Extracellular Space Nucleoplasm Cytosol Plasma Membrane Specific Granule Lumen NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Ankyrin Binding Identical Protein Binding Cullin Family Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Growth Post-translational Protein Modification Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization	Inflammatory Response Cellular Response To Extracellular Stimulus Pore Formation In Membrane Of Other Organism Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Pore Complex Assembly Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Pyroptosis
Pathways		RUNX1 regulates estrogen receptor mediated transcription Neddylation Estrogen-dependent gene expression Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation
Drugs
Diseases
GWAS		Hepcidin/transferrin saturation ratio ( 27846281) Systemic lupus erythematosus ( 28714469) vWF levels ( 30586737)	Schizophrenia ( 31268507)
Interacting Genes		17 interacting genes: ACTN1 ACTN3 ANK1 C8orf33 CDC23 CTNND1 EHHADH FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 PPIG PRPF31 SDCBP ZCCHC10	2 interacting genes: KCTD6 MFHAS1
Entrez ID		200845	79792
HPRD ID		13769	11014
Ensembl ID		ENSG00000168301	ENSG00000104518
Uniprot IDs		Q8NC69	P57764
PDB IDs			5NH1 5WQT 6AO4 6N9O
Enriched GO Terms of Interacting Partners?
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