BHLHE41 and PER2

Number of citations of the paper that reports this interaction (PubMedID 23555304)
16

Data Source:
BioGRID (two hybrid)

		BHLHE41	PER2
Description		basic helix-loop-helix family member e41	period circadian regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleus Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Cell Differentiation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Fatty Acid Metabolic Process Circadian Rhythm Response To Light Stimulus Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression Circadian Clock	Circadian Clock
Drugs
Diseases			Familial advanced sleep phase syndrome
GWAS		Response to bupropion and depression ( 27622933) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Chronotype ( 26955885 30696823 27494321) Morning vs. evening chronotype ( 26955885 26835600 27494321)
Interacting Genes		22 interacting genes: BHLHE40 CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DELEC1 FBXW11 GSK3B MYOD1 NONO PER2 PPP2CB PPP2R1B PPP2R5E RASD1 RORA RORC SIRT1 WDR5	19 interacting genes: BHLHE41 BTRC CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 MDM2 PER1 PER3 RORC TIMELESS TP53 TPT1 UBE2D1 UBE2D2 UBE2D3
Entrez ID		79365	8864
HPRD ID		16204	04575
Ensembl ID		ENSG00000123095	ENSG00000132326
Uniprot IDs		A0A024RAV8 Q8TAT1 Q9C0J9	O15055
PDB IDs
Enriched GO Terms of Interacting Partners?
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