PER2 and TIMELESS

Number of citations of the paper that reports this interaction (PubMedID 9856465)
85

Data Source:
HPRD (in vitro)

		PER2	TIMELESS
Description		period circadian regulator 2	timeless circadian regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm	Nuclear Chromosome Nuclear Chromatin Nucleus Nucleoplasm Replication Fork Protection Complex Site Of Double-strand Break
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Fatty Acid Metabolic Process Circadian Rhythm Response To Light Stimulus Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription Regulatory Region DNA Binding	DNA Replication Checkpoint Negative Regulation Of Transcription By RNA Polymerase II Morphogenesis Of An Epithelium DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Circadian Rhythm Detection Of Abiotic Stimulus Lung Development Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Replication Fork Arrest Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Replication Fork Protection Branching Morphogenesis Of An Epithelial Tube Cell Division Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Bleomycin Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair
Pathways		Circadian Clock	Processing of DNA double-strand break ends
Drugs
Diseases		Familial advanced sleep phase syndrome
GWAS		Chronotype ( 26955885 30696823 27494321) Morning vs. evening chronotype ( 26955885 26835600 27494321)	Axial length ( 24144296) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Interacting Genes		19 interacting genes: BHLHE41 BTRC CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 MDM2 PER1 PER3 RORC TIMELESS TP53 TPT1 UBE2D1 UBE2D2 UBE2D3	9 interacting genes: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1
Entrez ID		8864	8914
HPRD ID		04575	04864
Ensembl ID		ENSG00000132326	ENSG00000111602
Uniprot IDs		O15055	Q9UNS1
PDB IDs			4XHT 4XHU 4XHW 5MQI
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?