MAPKAPK3 and THAP12

Number of citations of the paper that reports this interaction (PubMedID 20484669)
10

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MAPKAPK3	THAP12
Description		MAPK activated protein kinase 3	THAP domain containing 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Chromatin
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Signal Transduction Negative Regulation Of Cell Proliferation
Pathways		p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs		2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Blood protein levels ( 28240269) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331)	Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433)
Interacting Genes		21 interacting genes: APP ATF1 BECN1 CHMP2A COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12	8 interacting genes: DDX58 DNAJC3 EIF2AK2 EIF2S1 MAPKAPK3 STK4 TACC1 TP53
Entrez ID		7867	5612
HPRD ID		03678	09567
Ensembl ID		ENSG00000114738	ENSG00000137492
Uniprot IDs		A0A024R2W7 Q16644	A0A140VJQ7 O43422
PDB IDs		3FHR 3FXW 3R1N 3SHE
Enriched GO Terms of Interacting Partners?
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