LAPTM5 and HEY1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
85

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAPTM5	HEY1
Description		lysosomal protein transmembrane 5	hes related family bHLH transcription factor with YRPW motif 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Integral Component Of Plasma Membrane Membrane	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Dimerization Activity
	Biological Process	Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Cell Differentiation Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Notch Signaling Involved In Heart Development Negative Regulation Of Biomineral Tissue Development Circulatory System Development Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369)
Interacting Genes		25 interacting genes: ANKRD13A DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 HERC1 HEY1 HEYL HUWE1 ITCH KRT7 LDLRAD1 NEDD4 NEDD4L RNF168 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC USP13 WWP1	17 interacting genes: ARNT CREBZF FBXW7 GATA1 HES1 HEY2 LAPTM5 MDM2 MYOD1 NTRK3 PLEKHF2 PRKD2 SKIL SMAD3 SMAD9 THTPA TP53
Entrez ID		7805	23462
HPRD ID		03280	04260
Ensembl ID		ENSG00000162511	ENSG00000164683
Uniprot IDs		Q13571 Q5TBB8	B4DEI9 Q9Y5J3
PDB IDs			2DB7
Enriched GO Terms of Interacting Partners?
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