ZNF207 and MAP2K2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ZNF207	MAP2K2
Description		zinc finger protein 207	mitogen-activated protein kinase kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Microtubule Spindle Matrix	Extracellular Region Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Microtubule Binding Heparin Binding Zinc Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule Bundle Formation Regulation Of Transcription, DNA-templated Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Microtubule Polymerization Protein Stabilization Cell Division Regulation Of Chromosome Segregation Mitotic Spindle Assembly	MAPK Cascade Activation Of MAPK Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Early Endosome To Late Endosome Transport
Pathways			MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Bosutinib Trametinib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Survival in pancreatic cancer ( 28470677)	Heel bone mineral density ( 30598549) Height ( 29782485) Pulse pressure ( 30224653)
Interacting Genes		8 interacting genes: ERBB3 HNRNPM HNRNPUL1 MAP2K2 POLR1B UBR5 WBP4 WDR77	18 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 RAF1 RGS12 RIPOR2 ZNF207
Entrez ID		7756	5605
HPRD ID		04576	03164
Ensembl ID		ENSG00000010244	ENSG00000126934
Uniprot IDs		O43670	P36507
PDB IDs			1S9I 4H3Q
Enriched GO Terms of Interacting Partners?
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